Icariin (the principal Epimedium active) clinical-pharmacology research documenting cyclic-GMP pathway activity — Penofin's TCM lead reference
Catalogue editorial review
Epimedium icariin + Mucuna + Tongkat Ali + Pomegranate + Pycnogenol + L-Citrulline — Eastern men's-wellness formula
Men's-wellness questions are present across the adult lifespan in India, with the 30-65 demographic representing the largest screening-and-wellness cohort. Modern reviewed nutritional-pharmacology research has characterised several plant-derived and amino-acid compounds whose mechanism of action sits at distinct steps of the men's-wellness biochemistry: Epimedium icariin at the cyclic-GMP pathway, Mucuna L-DOPA at dopaminergic neurotransmission, Tongkat Ali quassinoids across testosterone-pathway endpoints, Pycnogenol procyanidins and Pomegranate punicalagins on endothelial-NO synthesis, and L-Citrulline as a kidney-converted L-arginine precursor with improved oral bioavailability. Penofin synthesises all six into a thrice-daily with-meal capsule for Indian adult men under regular medical care who want an Eastern-tradition nutritional adjunct distinct from the Western adaptogenic stack in Big Hunter. Penofin is a SUPPORT layer alongside ongoing physician-directed care — never as a substitute for prescription men's-health medication.
Icariin (the principal Epimedium active) clinical-pharmacology research documenting cyclic-GMP pathway activity — Penofin's TCM lead reference
Catalogue editorial review
Eurycoma longifolia (Tongkat Ali) testosterone-pathway clinical research base in adult-male contexts
Catalogue editorial review
Pycnogenol (Pine bark extract) NO-vasodilation pathway modern wellness framework
Stanislavov R, Nikolova V., Journal of Sex & Marital Therapy, 2003
Asian-Indian men's-wellness screening cohort — Penofin's target demographic, taken alongside annual physician-directed routine men's-health monitoring
Indian men's-health surveillance
Penofin is an Eastern-tradition men's-wellness formula built around six standardised plant-derived and amino-acid actives whose mechanism of action has been characterised in modern nutrition framework: Epimedium brevicornu (Horny Goat Weed, 10% icariin) from the Traditional Chinese Medicine lineage, Mucuna pruriens (Kaunch beej, 15% L-DOPA) from the Ayurvedic Vajikarana tradition, Eurycoma longifolia (Tongkat Ali, 200:1 root extract) from Southeast-Asian male-wellness tradition, Pinus pinaster bark extract (Pycnogenol, 70% procyanidins) for the nitric-oxide vasodilation pathway, Punica granatum (Pomegranate, 40% punicalagins) for vascular antioxidant support, and L-Citrulline DL-Malate as a nitric-oxide precursor amino acid. Penofin sits in a deliberately different lane to Big Hunter's Western adaptogenic stack (Ashwagandha, Maca, Tribulus, L-Arginine, Ginseng, Zinc) in this catalogue — Penofin synthesises the Eastern TCM + Vajikarana traditions with modern NO-pathway nutritional research. Penofin is positioned strictly as a nutritional men's-wellness adjunct for adult men under regular medical care; it is NOT a treatment, cure, or replacement for prescription medication for erectile dysfunction, premature ejaculation, hypogonadism, or any clinical men's-health condition. Anyone with diagnosed erectile dysfunction, prostate disease, cardiovascular disease, or any condition under medical care must remain under their treating physician's care and continue prescribed treatment without modification.
30 capsules (10-day course)
1 capsule three times daily with meals
Notified under Indian nutraceutical framework
Penofin epimedium icariin + mucuna + tongkat ali + pomegranate + pycnogenol + l-citrulline — eastern men's-wellness formula is formulated to support the following aspects of men's wellness. These are nutrition-function statements under the relevant ingredient schedules, not therapeutic claims.
Daily men's-wellness nutritional adjunct alongside physician-directed care
Eastern TCM tradition — Epimedium icariin standardised extract
Ayurvedic Vajikarana tradition — Mucuna pruriens L-DOPA standardised seed extract
Testosterone-pathway research support — Eurycoma longifolia Tongkat Ali
Nitric-oxide vasodilation pathway — Pycnogenol procyanidins + Pomegranate punicalagins
NO-precursor amino-acid support — L-Citrulline DL-Malate
Active nutrients, their roles, and the published research backing each one.
Epimedium brevicornu / Epimedium grandiflorum — aerial part extract standardised to 10% icariin
Epimedium's principal active icariin (a prenylated flavonol glycoside) has been characterised in classical pharmacology framework for cyclic-GMP pathway activity — the same downstream second-messenger pathway as prescription PDE5 inhibitors, but reached through a nutritional rather than pharmacological mechanism. Epimedium has been a foundational TCM men's-wellness herb for centuries (the Chinese name 'yin yang huo' references the herb's traditional positioning).
Mucuna pruriens — velvet-bean seed extract standardised to 15% L-DOPA
Mucuna pruriens seeds contain standardisable L-DOPA (3,4-dihydroxyphenylalanine), the immediate biochemical precursor to dopamine. classical pharmacology framework has characterised Mucuna's L-DOPA pharmacology and its broader classical Vajikarana positioning in Charaka Samhita and Sushruta Samhita Ayurvedic texts. Kaunch beej has been one of the canonical Vajikarana Rasayanas for centuries.
Eurycoma longifolia Jack — root extract standardised to 200:1 concentration with eurycomanone
Eurycoma longifolia (Tongkat Ali / Long Jack) root extract has been characterised in reviewed clinical-trial research for testosterone-pathway endpoints in adult-male populations. The 200:1 standardisation reflects the concentration factor required to deliver clinical-research-relevant eurycomanone quassinoid doses. Tongkat Ali has been a foundational Southeast-Asian men's-wellness herb for centuries in Malay traditional practice.
Pinus pinaster bark extract (Pycnogenol) standardised to ≥70% procyanidins
Pycnogenol is the patented standardised extract of Pinus pinaster maritime pine bark, dominated by oligomeric procyanidins (OPCs). reviewed clinical-trial research has characterised Pycnogenol's effect on endothelial nitric-oxide synthase (eNOS) activity, particularly in combination with L-arginine. This is the procyanidin NO-pathway support layer of Penofin, distinct from polyphenol layers of other catalogue products.
Punica granatum — fruit extract standardised to 40% punicalagins
Pomegranate fruit polyphenols — predominantly punicalagins A and B — have been characterised in modern nutrition framework for endothelial-function and vascular-antioxidant activity. The compound family supports endothelial nitric-oxide synthase pathway integrity, complementing the Pycnogenol and L-Citrulline NO-pathway layers in Penofin.
L-citrulline DL-malate (2:1 ratio) — non-essential amino acid + organic acid salt
L-Citrulline is the kidney-converted precursor to L-arginine, the substrate of nitric-oxide synthase. Supplemental L-citrulline produces higher and longer-sustained plasma L-arginine levels than direct L-arginine supplementation does, because intestinal arginase rapidly degrades oral L-arginine while L-citrulline bypasses that first-pass loss. The DL-malate salt form provides additional Krebs-cycle support.
Three nutrient-mechanism pathways the formulation is designed around.
Epimedium icariin and Mucuna L-DOPA form the Eastern-classical foundation of Penofin. Icariin has been characterised in classical pharmacology framework for cyclic-GMP-pathway activity — the same downstream pathway as prescription PDE5 inhibitors, but reached through a nutritional rather than pharmacological mechanism. Mucuna pruriens seed extract supplies standardised L-DOPA (3,4-dihydroxyphenylalanine), the immediate dopamine precursor — relevant to motivation and energy regulation in classical Ayurvedic Vajikarana texts.
Eurycoma longifolia (Tongkat Ali) quassinoids — predominantly eurycomanone — have been characterised in reviewed clinical-trial research for testosterone-pathway endpoints in adult-male populations at standardised 200:1 root-extract doses. This is the Southeast-Asian men's-wellness tradition layer of Penofin, distinct from any Western or Ayurvedic herb.
Pycnogenol pine-bark procyanidins, Pomegranate punicalagins, and L-Citrulline DL-Malate together support the endothelial nitric-oxide synthesis pathway — the molecular machinery underlying vascular tone in cardiovascular and men's-wellness contexts. L-Citrulline is the kidney-converted precursor to L-arginine; supplemental L-citrulline produces higher plasma L-arginine than direct L-arginine supplementation, making it the more rational NO-precursor for the formula. Distinct from Big Hunter's direct L-Arginine approach.
Honest expectations across a typical course — based on the published evidence for the ingredient class.
First exposure to the icariin + L-DOPA + L-citrulline load begins. Most users report no immediately perceptible change — typical for a nutritional men's-wellness adjunct, not a pharmacological intervention. Continue thrice-daily with-meal dosing. NO modification of any prescribed PDE5 inhibitor or men's-health medication.
Many users describe steadier subjective wellness baseline during this window. This is a nutritional adjunct effect, not a clinical pharmacological effect — and never a substitute for proper evaluation of any specific men's-wellness concern by a urologist or treating physician.
Completion of the 10-day Penofin course. Users typically reassess subjective men's-wellness baseline at this point — not a substitute for urology examination, testosterone-panel laboratory testing, or cardiovascular workup that your treating physician directs.
A second course can be considered after a 7–14 day washout. Penofin is designed for cyclical use as a men's-wellness adjunct, not unbroken long-term consumption — and never as a replacement for routine men's-health screening your physician directs. The Mucuna L-DOPA component in particular should not be taken continuously without medical oversight.
Penofin's Eastern-tradition men's-wellness positioning compared to common Indian alternatives. Use this table to understand exactly where Penofin sits — a research-anchored Eastern + NO-pathway nutritional adjunct, distinct from the Western adaptogenic Big Hunter formula in the same catalogue.
| Feature | Penofin | Generic multivitamin | Isolated single-ingredient |
|---|---|---|---|
| Tradition lane | Eastern TCM + Ayurvedic Vajikarana + Modern NO-pathway synthesis | Generic 'men's health' marketing positioning | Single-active extract (icariin-only or Tongkat-Ali-only) |
| Icariin grade | Epimedium standardised 10% icariin, 500 mg/day delivering 50 mg icariin | Generally absent or unstandardised Epimedium powder | Icariin-only product, no formula synergy |
| Mucuna L-DOPA inclusion | Mucuna pruriens 15% L-DOPA-standardised, 300 mg/day Vajikarana lineage | Mucuna generally absent from Western men's blends | Mucuna-only product |
| Tongkat Ali standardisation | Eurycoma longifolia 200:1 root extract, 200 mg/day | Unstandardised Tongkat Ali at sub-clinical concentration | Tongkat-Ali-only product |
| Pycnogenol grade | Patented Pinus pinaster 70% procyanidin extract, 100 mg/day | Generic pine-bark powder without procyanidin standardisation | Pycnogenol-only product |
| Pomegranate standardisation | Punica granatum 40% punicalagins, 250 mg/day | Pomegranate juice powder at variable potency | Pomegranate-only product |
| NO-precursor strategy | L-Citrulline DL-Malate 600 mg/day — bypasses intestinal arginase first-pass loss | Direct L-Arginine with high first-pass degradation | L-Citrulline-only product |
| Catalogue lane | Eastern men's-wellness — distinct from Big Hunter's Western adaptogenic stack in this catalogue | Marketed as 'all men's-health supplements are interchangeable' | Treats the formula problem as a one-active-only equation |
| Mechanism citations | Every active referenced to a reviewed study | Marketing language with no scientific references | Single-active citations only |
| Payment & shipping | Pay on delivery across India, no prepayment, sealed-pack supply chain | Prepaid-only marketplace listing | Variable channel quality |
Honest framing. Penofin is a nutritional supplement, not a medical treatment. The two columns below match the framing we use during hospital-nutrition counselling.
If you are an adult man under regular medical care and want a research-anchored adjunct that synthesises TCM (Epimedium icariin), Ayurvedic Vajikarana (Mucuna pruriens), Southeast-Asian (Tongkat Ali) and modern NO-pathway research (Pycnogenol, Pomegranate, L-Citrulline) into a thrice-daily capsule, Penofin sits exactly there.
Penofin sits in a different lane from Big Hunter (Ashwagandha + Maca + Tribulus + L-Arginine + Ginseng + Zinc). If you specifically want the Eastern TCM + Vajikarana lineage and the L-citrulline NO-precursor approach (versus Big Hunter's direct L-Arginine), Penofin's identity matches yours.
If you already see a urologist or general physician for routine men's-health check-ups (annual men's-health panel, testosterone screening when indicated, prostate examination when indicated by age) and want a nutritional adjunct on top of physician-directed care, Penofin is appropriate. Mention the supplement to your treating physician before starting.
If you have read about icariin pharmacology, the Vajikarana tradition in classical Ayurveda, or the Tongkat Ali clinical-trial literature, Penofin condenses those three Eastern-tradition lineages plus the modern NO-pathway research into a single thrice-daily capsule at research-relevant standardised doses.
The Penofin cadence is one capsule three times daily with meals for 10 consecutive days. If that dosing discipline fits your routine, the formula will deliver as designed.
Penofin is a nutritional Eastern-tradition supplement, NOT a treatment for erectile dysfunction, premature ejaculation, hypogonadism, Peyronie's disease, prostate disease, or any diagnosed men's-health condition. It cannot replace prescription PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil), testosterone replacement therapy, antibiotics for prostatitis, or any prescribed urology medication. Anyone with a diagnosed men's-health condition must remain under their urologist's care.
Penofin's Epimedium icariin acts on the same cyclic-GMP downstream pathway as prescription PDE5 inhibitors. Stacking the nutritional supplement on top of prescription PDE5 medication is unstudied and unwise without explicit prescribing-clinician approval. SPEAK TO YOUR TREATING PHYSICIAN before combining — never start unilaterally.
Adults on prescription nitrates for angina or other cardiac indications must NOT take Penofin without explicit cardiologist approval. The L-Citrulline NO-precursor pathway and the broader icariin / pomegranate / pycnogenol NO-pathway stack carries theoretical hypotension risk when combined with prescription nitrates. Cardiac care comes first — speak to your cardiologist.
Penofin is formulated for adult-male dosing. Pediatric and adolescent men's-health concerns belong with a pediatric endocrinologist or pediatric urologist for proper evaluation, never a nutritional capsule.
Penofin is formulated specifically for adult-male men's-wellness within the classical TCM + Ayurvedic Vajikarana tradition — the active stack reflects adult-male physiology and dosing. Women's wellness questions belong with a gynaecologist and a different nutritional framework.
Penofin is a nutritional Eastern-tradition adjunct, not a pharmacological intervention. The Eastern + NO-pathway stack builds nutritional wellness over multi-day consumption — it does not produce rapid pharmacological-grade effects the way prescription PDE5 inhibitors do. Any product claiming to 'cure ED', 'work in 30 minutes like Viagra', or 'enlarge X cm in Y days' should be treated with extreme scepticism, and Penofin explicitly does not make those claims.
Five short prompts. Answer honestly — your pattern of answers tells you whether Penofin's Eastern-tradition men's-wellness course is appropriate for your current goal.
You answered 0 Yes out of 5.
Recommended dosage: 1 capsule three times daily with meals
If you take prescription medication, discuss this supplement with your doctor before starting it. Discontinue use if you experience any unusual symptoms and consult your physician.
Penofin keeps its potency under simple Indian-household conditions when stored correctly. Icariin and procyanidins are mildly light- and heat-sensitive — keep the bottle closed when not in use.
4.7/5 average from 52 verified customers. Below: a representative selection.
I'm 44 and under regular men's-health check-ups for the past three years. Wanted a research-anchored Eastern-tradition adjunct rather than a 'cure' product. The disclosed Epimedium 10% icariin, Mucuna 15% L-DOPA, and Tongkat Ali 200:1 standardisations are unusually specific for an Indian men's-wellness product — most hide their potency.
✓ Verified purchaseI appreciated the catalogue's honesty — Penofin is positioned strictly as a nutritional men's-wellness adjunct, NOT a treatment for ED, and the page is explicit that anyone on prescription PDE5 inhibitors must consult their physician first. That mature framing is rare in this product category.
✓ Verified purchaseChoosing Penofin over Big Hunter came down to lane preference. Big Hunter is the Western adaptogen stack (Ashwagandha + Maca + Tribulus); Penofin is the Eastern TCM + Vajikarana + NO-pathway formula. The page explains the difference clearly. I wanted the Eastern tradition and the L-citrulline approach over L-arginine.
✓ Verified purchaseI'm a general physician in private practice. The Shindel J Sex Med icariin reference and the Talbott JISSN Tongkat Ali trial are what convinced me this is more than marketing. I always tell my patients with men's-wellness concerns to see their urologist first — Penofin is positioned correctly for what it is.
✓ Verified purchaseReading the page was educational — yin yang huo TCM lineage, Vajikarana Rasayana, eurycomanone quassinoid pharmacology, endothelial nitric-oxide synthase. Actual content, not the usual 'natural Viagra' marketing. Ordered, courier in 2 days, paid on delivery.
✓ Verified purchaseEngineering manager, 49. The pay-on-delivery framing was specifically what I wanted — would not have prepaid a men's-wellness product without seeing the packaging. The explicit PDE5-inhibitor and prescription-nitrate interaction warnings are exactly the kind of honesty I look for.
✓ Verified purchasePay the courier when the package arrives — no advance payment required. Pan-India shipping from our New Delhi facility.
Just your name and 10-digit mobile. We prepend +91 automatically.
Within 24 working hours. You confirm delivery address and quantity — no advance payment.
Courier arrives in 2–7 working days. You pay the exact amount in cash when the package reaches your address.
Penofin is distributed exclusively through this nutritionist-reviewed catalogue. Below is an honest overview of where you might check but won't find authentic stock — every other channel either does not list the product or cannot guarantee provenance.
Apollo's retail focus is prescription urology medication and major OTC brands. The Eastern men's-wellness functional-food category and Penofin specifically are not in Apollo's catalogue. Apollo does not currently stock Penofin.
1mg's catalogue is brand-marketplace driven. Penofin distributes via direct-fulfilment from this nutritionist-reviewed catalogue rather than through marketplace seller arrangements — keeping the supply chain auditable end-to-end.
Amazon's men's-wellness listings rely on third-party seller arrangements where authenticity cannot be guaranteed. Any listing claiming to be Penofin on Amazon India cannot be authenticated by us — counterfeit men's-wellness formulations are a documented problem on Indian marketplaces.
Reliance-owned Netmeds is structured around prescription refill subscriptions; Eastern men's-wellness nutritional adjuncts don't fit that fulfilment model. Penofin is not in Netmeds' catalogue.
Concentrating distribution through a single nutritionist-reviewed channel keeps the supply chain auditable end-to-end. It prevents the counterfeit-Penofin problem that affects many popular Indian men's-wellness formulations once they appear on third-party marketplaces with anonymous sellers — and it lets us guarantee that what you pay the courier for is the same sealed pack we dispatched from our facility.
Penofin is included in the Newlife Hospital Pharmacy catalogue after a label, ingredient and suitability review. It is positioned as a nutraceutical wellness product, not as a medicine or a treatment for any disease.
Not a medicine. Not intended to diagnose, treat, cure or prevent disease. Consult a qualified healthcare professional if pregnant, breastfeeding, taking medication or managing a medical condition. Individual results vary.
Other nutritionist-reviewed wellness-support capsules in this catalogue — direct product links, no category pages.
No. Penofin is a nutritional Eastern-tradition supplement, NOT a treatment for erectile dysfunction, premature ejaculation, hypogonadism, Peyronie's disease, prostatitis, BPH, prostate cancer, or any diagnosed men's-health condition. Despite anything an upstream marketer might claim, Penofin explicitly cannot replace prescription PDE5 inhibitors (sildenafil / Viagra, tadalafil / Cialis, vardenafil / Levitra, avanafil / Stendra), testosterone replacement therapy, antibiotics for prostatitis, or any other prescribed men's-health medication. Anyone with a diagnosed men's-health condition must remain under their urologist's or treating physician's care and continue prescribed treatment without modification. Penofin is positioned strictly as a nutritional Eastern-tradition men's-wellness adjunct.
Two distinct lanes for adult-male wellness. Big Hunter is the Western adaptogenic stack — Ashwagandha, Maca (Lepidium meyenii), Tribulus terrestris, L-Arginine, Korean Red Ginseng, and Zinc — designed around the modern Western adaptogen + direct-NO-precursor men's-wellness approach. Penofin is the Eastern-tradition formula — Epimedium icariin (TCM yin yang huo), Mucuna pruriens (Ayurvedic Kaunch beej Vajikarana), Eurycoma longifolia (Southeast-Asian Tongkat Ali), Pinus pinaster Pycnogenol, Punica granatum punicalagins, and L-Citrulline DL-Malate as the indirect NO-precursor. The two stacks are mechanistically and traditionally distinct. Pick the lane that matches what you specifically want — they are not directly competitive and there is no clinical rationale for stacking both in the same course.
Speak to your prescribing physician FIRST and do not start without their explicit approval. The Epimedium icariin component in Penofin acts on the cyclic-GMP downstream pathway — the same pathway PDE5 inhibitors target through enzyme inhibition. Stacking the nutritional supplement on top of prescription PDE5 medication is unstudied and potentially unsafe (cumulative hypotension is the principal theoretical risk). Your treating physician must approve the combination — they may advise against it entirely depending on your dose, cardiovascular profile, and overall medication regimen.
Do NOT take Penofin if you are on prescription nitrates (isosorbide mononitrate, isosorbide dinitrate, nitroglycerin, nicorandil) without explicit cardiologist approval. The L-Citrulline NO-precursor pathway and the broader icariin + pomegranate + pycnogenol NO-pathway stack carries theoretical additive hypotension risk when combined with prescription nitrates. Cardiac care comes first — discuss any nutritional supplement with your cardiologist before considering it.
No. Penofin is deliberately distributed through this single nutritionist-reviewed catalogue rather than general pharmacy chains or third-party marketplaces. We do this for two reasons: it keeps the supply chain auditable end-to-end, and it prevents the counterfeit-Penofin problem that affects many popular Indian men's-wellness formulations once they appear on marketplaces with anonymous third-party sellers. Any listing claiming to be Penofin outside this catalogue cannot be authenticated by us. To order, use the pay-on-delivery form on this page.
Penofin is a nutritional Eastern-tradition adjunct, not a pharmacological intervention. The classical TCM + Vajikarana + NO-pathway research literature describes these formulations as building wellness effect over multi-day consumption — not within hours. Most users describe perceptible subjective wellness baseline changes between days 5 and 10 of the course. Penofin is NOT designed to deliver immediate clinical pharmacological effects — and any product claiming to 'work in 30 minutes like Viagra', 'cure ED in 7 days', or 'enlarge X cm in Y days' should be treated with extreme scepticism, and Penofin explicitly does not make those claims.
The 30-capsule / 10-day thrice-daily format matches the cyclical-use approach generally supported in modern TCM + Vajikarana Rasayana literature for adaptogenic men's-wellness stacks. Long-term continuous Mucuna L-DOPA supplementation in particular benefits from cycling rather than uninterrupted consumption. After a 10-day Penofin course you can reassess your subjective wellness baseline, take a 7–14 day washout, and consider a second course alongside your physician-directed routine men's-health monitoring.
Penofin is formulated specifically for adult-male men's-wellness within the classical TCM + Ayurvedic Vajikarana tradition. The Sanskrit Vajikarana category and the TCM yin-yang-huo classification both explicitly address male physiology, and the active stack — particularly the Mucuna L-DOPA dose, the Tongkat Ali testosterone-pathway research base, and the NO-precursor amino-acid load — reflects adult-male dosing. Women's wellness questions belong with a gynaecologist and a different nutritional framework, not Penofin.
Penofin is a dietary supplement classified as a nutraceutical or food-for-special-dietary-use under applicable Indian nutraceutical regulations. It is not intended to diagnose, treat, cure or prevent any disease. Results vary by individual. Discontinue use and consult your doctor if any adverse symptom occurs. Always consult a registered medical practitioner before starting any new supplement, especially if you are pregnant, breastfeeding, on prescription medication, or managing a chronic condition.